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Robust estimates of standard errors were employed to accommodate clustering of data within hospitals.
Patients will be clustered by clinic, but we have no data on which to estimate intraclass correlation for the HADS scores; so will assume a design effect of deff = 1.5 to accommodate clustering, and hence we will require 600 patients in all; across five clinics, so we will seek to enrol 120 patients per site.
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The method is extended to accommodate clustered tensegrity structures.
Because RF++ is constructed to accommodate clustered data, it summarizes classification both at the replicate and subject level.
Another analytic option that will be considered is generalised estimating equations (GEE), 55 which can also accommodate clustered, serially correlated data with missing values.
An extended Wilcoxon rank-sum test that accommodates clustered data was used for comparisons between control and Mcoln1 −/− groups for non-normally distributed data.
Differences between arms will be tested by multi-level modelling to accommodate cluster randomisation.
A mixed effects model will be used to model the data and test the hypothesis of no effect from team training to accommodate cluster effects and time effects.
This draws parallels with the analysis of IPD from multi-centre clinical trials, accommodating clustering within treatment centres; however, in a multi-centre trial the treatment effect is not often random, whereas in a meta-analysis it often is.
Specifically, logically full-meshed optical burst switching rings are employed to compose a lattice substrate, which provide dense connectivity for small groups of ToR switches to accommodate highly clustered and dynamic regional data traffic, while a reconfigurable wavelength circuit switching plane offers direct connections among the racks to effectively reduce overall network diameter.
The impact of the intervention was assessed using a mixed effects logistic regression model, accommodating for clustering at GP level.
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