Peptide transporters represent excellent targets for the delivery of pharmacologically active compounds because their substrate-binding site can accommodate a wide range of molecules of differing size, hydrophobicity and charge.
For most days of the year, a site can accommodate a predictable flow of traffic.
Late in 2010, the group announced plans to redevelop the Nuffield Health Guildford Hospital site to accommodate a range of new services, and to merge the services of the Guildford Clinic fully within the upgraded Guildford Hospital.
Broun calculated that a 1500 acre site would accommodate a total of 5,830,500 individual graves in a single layer.
Crystallography has revealed that the ATP-binding site of CDK2 can accommodate a number of diverse molecular frameworks, exploiting various sites of interaction.
Many Stat92E targets contain paired binding sites, to accommodate a dimer of Stat92E (Flaherty et al, 2009).
The site can accommodate a dizzying array of items, from bottles, cans and newspapers to crockery, batteries, nappies, cigarette lighters, ballpoint pens and an improbably large number of broken mirrors.
Choosing the crystal coordinates of TK (Fig. S1 in Additional File 2) in complex with its natural substrate (deoxythymidine) was reasonable since the active site can accommodate a broad variety of ligands.
From the ΔCcMreBdh co-crystal structures with ADP and AMPPNP, it is clear that the active site could well accommodate a guanidine instead of an adenine as the major contacts are with the ribose and phosphate moieties of the nucleotide, a feature, again, shared with ParM (Gayathri et al., 2013).
Accommodate a variety of learning styles.
