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Our previous studies have shown that the N-terminus of the B-chain can be truncated by six residues [ 34] or modified to accommodate a functional moiety such as a biotin [ 35] or large fluorophore [ 18] without significant loss of activity.
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If distinct, two possible substrates of TrpH may include 2′-substituted 3′,5′-bisphosphonucleotides or 2′,5′-bisphosphonucleotides, because the relatively small glycine residue can be envisaged to accommodate a larger functional group at the enzyme active site.
We have found this transfer function form to be useful because it is simple yet flexible enough to accommodate a variety of biologically relevant functional relationships including linear, sigmoidal, and digital.
Self-management of pain, therefore, should be encouraged, whenever possible, and strategies in place to facilitate this process and accommodate any functional or sensory deficits as a result of aging and disease [ 49].
An organisation properly set up according to these model tenets can accommodate a higher measure of territorial-functional differentiation than can a state-type entity.
True intron sliding is rare [ 52- 54], but this is not the first example of a phase change by a sliding event being accommodated in a functional gene [ 55].
In order to accommodate a patient group with heterogeneous symptoms, the functional retraining exercises may be performed statically and/or dynamically during various functional activities (eg step up, step down, sit to stand).
This procedure was used as there was non-linearity in this model and PROC NLIN is able to accommodate a range of linear and non-linear functional forms.
In contrast, the distal aryl ring was more tolerant to functional group modifications and could accommodate a variety of substitutes at the C-2 or C-3 positions.
This functional substitution of the R with a K in GlSec61α may have taken place to accommodate a G-rich rRNA.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com