The results suggest that, as for breast cancer, loss of Fhit and Wwox expression might have a role in the pathogenesis of basaloid differentiation in salivary gland neoplasms; alternatively, differences in chromatin structure at chromosome fragile regions might make fragile genes more accessible to DNA damage and rearrangement early during preneoplastic stages of basaloid cancers.
Off-hand remarks, political statements, or indiscriminate photos can be easily accessible to employers, and can damage your professional image in a nanosecond.
It has also been hypothesized [ 142, 146, 147] that densely packed chromatin structures must be transiently loosened by topoisomerase to render the DNA damage sites accessible to excision repair enzymes, particularly for access of repair endonuleases that excise the damaged site [ 150- 152].
Enabled by the shear sliding, as well as periodic changes in elastic modulus, such a functionally graded multilayer structure was effective in lowering the magnitude and extent of stress concentrations, thereby extending the damage tolerance accessible to a ceramic coating.
In addition, existence of viable bacteria in dormant forms that are not accessible to antibiotics and antibiotic-related damage to the mucosal immunity can also be observed.
The findings indicate that the high damage tolerance potentially accessible to glassy materials can extend beyond the benchmark ranges towards levels previously inaccessible to metallic crystalline amorphous composites.
Nevertheless, the Fe-S cluster may still be accessible to small molecules that may cause damage.
The buildings have water damage, are not fully accessible to people in wheelchairs and have inefficient heating and air-conditioning systems.
After the Columbia accident, this team was criticized for not being accessible to concerns expressed by lower-level engineers about possible launching damage to the shuttle.
"The challenge is to find a way to make that resource accessible to a wide variety of people — meaning the elderly, disabled and families — but that doesn't damage the resource itself.
