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The model analysis identified several kinetic orders with relatively high sensitivities, but because these reflect structural features of enzymatic processes, they are unlikely to present accessible targets for drug treatment.
Along with NCL and EPL, the traceless Staudinger ligation has made proteins accessible targets for chemical synthesis and semisynthesis.
Along with NCL and EPL, the traceless Staudinger ligation has made proteins more readily accessible targets for chemical synthesis and semisynthesis.
The primary reason for this study was to investigate the initiating mechanisms and complex interplay between different cell types of the heart that occur during the earliest stages of progressive heart disease, with a view to revealing accessible targets for development of novel therapeutics.
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"Yes, you're targeting people's beliefs, but you're not just targeting easily accessible beliefs.
They serve as security guards at checkpoints in Khyber-Pakhtunkwha Province, but their graduation, officials said, provided an accessible target for the militants to drive home their message.
Now, with his shift to left field, Knoblauch has become a much more tempting and accessible target for derision, and fans fired away tonight, with words and coins and plastic bottles.
As a monolayer of cells critical to photoreceptor function and survival, the RPE is an ideally accessible target for cellular therapy.
From a public health perspective, obesity is an accessible target for intervention programs designed to reduce the incidence of diabetes [3].
Mammalian thioredoxin reductase (TrxR) is a cellular antioxidant containing selenocysteine (Sec) in its C-terminal redox center, a highly accessible target for electrophilic modification.
As stated before, the ECD of HER-2, which represents the accessible target for immunotherapy with Trastuzumab, can be shed (Hayes et al, 2001) and splice variants of HER-2 with deletion in ECD exons can occur (Christianson et al, 1998; Kwong and Hung, 1998; Molina et al, 2002).
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