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We think this represents the best combination of a biologically relevant outcome and an experimentally accessible readout for each model.
Platelet Mmp-Index proved to be a highly reproducible, easily accessible readout for mitochondrial integrity and showed good correlation with clinical disease severity during clinical course, correlated with clinical outcome, and normalized with recovery.
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Identification of biomarkers that provide rapid and accessible readouts of drug exposure, activity, toxicity or efficacy is becoming increasingly important in the clinical development of novel molecularly targeted therapeutics.
Versatile genetic strategies and easy, accessible readouts for gene functions can be used to study a broad range of biological problems in the areas of development, physiology, and behavior.
A more easily accessible and earlier tissue aging readout would thus provide a valuable model for further studies on organ aging.
All ultrasonic cleaner control buttons and readouts should be easily accessible.
The as-produced glucose could be monitored by using a widely accessible PGM for in situ amplified digital readout.
Readout parameters that were previously only accessible in the classic rodent model are now established for a new NHP model.
Because of its external fertilization, transparency and small brain size, the larval zebrafish brain is nearly entirely accessible to two-photon stimulation and to activity readouts without any invasive surgery.
Using this approach, we measured a large number of parameters and readouts, which provide researchers with an easily accessible method for describing locomotor defects quantitatively and qualitatively.
Nevertheless, the findings of this study could be the basis for the development of easily accessible PD biomarkers in the blood of PD patients and might turn out to be valuable readouts to judge future clinical studies on disease-modifying therapies.
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CEO of Professional Science Editing for Scientists @ prosciediting.com