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Some of the most accessible peaks in the Alps surround the St Nicholas valley where Zermatt nestles.
Only expressed genes and accessible peaks in more than 10% of the cells were used and normalized by deconvolving size factors from cell pools43.
Camp Simpona also serves as a basecamp for the steep climb to the summit of Marojejy Massif, one of Madagascar's highest but most accessible peaks.
This low influence of historical contingency suggests that the original host N. tabacum represents a case of a single accessible fitness peak, or a very limited number of accessible peaks with similar height, otherwise new mutations fixed during Phase 1 might make alternative and more diverse peaks available [ 30].
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Their most accessible peak is Jabal Akhdar ("Green Mountain" in Arabic, though it's chiefly sun-scorched limestone); alongside, Jabal Shams soars over 3,000 metres.
In terms of adaptive landscape, a significant historical contingency would imply that N. tabacum represents an environment with multiple fitness peaks, whereas a lack of historical contingency would suggest that the ancestral host represents an environment with a single accessible peak [ 30].
DOI: http://dx.doi.org/10.7554/eLife.09406.010 10.7554/eLiFigure06.011 Figure 4 figure supplement 1. H3K4me3 Chip-Seq analysis of human fetal muscle (top, GEO Accession GSM1160200) and DNAse-Seq analysis of fetal human heart (bottom, GEO Accession GSM665817) identifies an internal chromatin accessible peak overlying the alternative TTN promoter.
Local-ATAC-QTLs have the largest effects on co-accessible peaks, are associated with gene expression and are enriched for autoimmune disease variants.
Second, the difference between the global peak and accessible local peaks may be negligible, in which case differences in adaptive magnitude across populations of different sizes will be similarly small.
The accessible chromatin peak at the far right is the conventional TTN promoter.
For example, in the Feather River, CA, spring-run fish enter freshwater in a reproductively immature state many months prior to spawning, which enabled them historically to reach high-elevation breeding grounds only accessible during peak springwater flows.
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