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As a result, it is likely that Ynd1-associating proteins identified by this method interact with the Ynd1 cytosolic tail, and are thus also accessible for interaction with E4orf4.
According to this structure, the C-terminus of TRPV4 is exposed outside and accessible for interaction with other proteins.
The function of linear motifs strongly depends on the context, e.g. functional instances mainly occur inside flexible regions that are accessible for interaction.
Consequently, this result predicts that the TID in TAp63αMI should also be accessible for interaction with an external TA domain.
Interestingly the mutation is exactly in the middle of the loop, at a site readily accessible for interaction with other molecules.
Because MBP may bind actin filaments, the intracellular concentration of actin accessible for interaction with MBP may be estimated to be 20 40 μM.
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Such an exposure may render RAN accessible for interactions with other proteins such as MAD2B.
The finding of disease-associated substitutions that are directly adjacent (positions 101 and 181) in the hydrophobic core structure of the internal anti-parallel beta sheet and a non-bonded cysteine residue in the flexible loop that is accessible for interactions is a new discovery.
By contrast, CrkI has an extended structure in which both SH2 and nSH3 are freely accessible for interactions with target proteins.
To summarize, lowering the concentration of plasma membrane PtdIns(4,5) P2 accessible for interactions with CGPs [and other PtdIns(4,5) P2-binding proteins] inhibits syncytium formation.
We note that in the EM reconstruction the flanks of the CTD B complex are easily accessible for interactions with the primase.
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