In the DCM, large numbers of accessible constraint topologies are sampled, their associated free energies calculated, and then the native free energy basin is identified.
As such, thermal fluctuations of noncovalent interactions are expressed through an ensemble of accessible constraint topologies, each with its own Boltzmann factor.
The high ambient pressure, but also the fact that the detector is hardly accessible, put severe constraints on the mechanical design of the detection units of the telescope.
We also use fitness graphs in order to give a new brief proof of the equivalent characterizations of fitness landscapes lacking genetic constraints on accessible mutational trajectories.
The study plan provided for the assessment of all 127 public CEmONC facilities, but 49 of them were not accessible due to security constraints at the time of the field work.
In 2009 10, a needs assessment sought to examine EmONC services at all 127 designated EmONC facilities; however, 49 of those facilities (16 CHCs, 25 district hospitals, five provincial hospitals and three national specialty hospitals) were not accessible due to security constraints [ 14].
While it was unsurprising that selective constraint on conserved miRNA sites was stronger than on non-conserved miRNA sites and selective constraint on accessible sites fell between these two extremes, the aim of our study was to determine the precise magnitude of the differences in selective constraint between these different data sets.
In the Discussion, we argue that the similarity between our and Harms' work is the strong genetic constraint on accessible mutations dictated by biophysical requirements.
We describe here a new application of a straightforward SSNMR technique which, when combined with FTIR spectroscopy, reports quantitatively on the orientation of the peptide molecules within the nanotube structure, thereby providing an additional structural constraint not accessible to MAS SSNMR.
We emphasize the advantages in terms of flexibility with respect of previous methods making use of specially designed retarding phase plates; however, the nature of the mirror imposes constraints on the accessible wavefronts, whose consequences are analyzed.
