For example, acetylation of N-terminal lysine residues generates a more open and accessible chromatin configuration [3] [5] and is associated with increased gene expression.
This process goes along with an easily accessible chromatin configuration, so that transcription is facilitated [ 26].
This observation suggests that the regions in which these class Ib genes are located may have an open or accessible chromatin configuration from the time of the first observable developmental stage.
On the contrary, the pseudo V genes within the chicken Ig loci are unlikely to be transcribed, and the absence of transcription or their less accessible chromatin configuration may favor GC.
For example, histone variant H3.3, which is preferentially deposited at gene regulatory elements, is enriched in lysine methylation associated with active gene transcription (Ng and Gurdon 2008), which suggests that it may facilitate recruitment of SET proteins, presumably by promoting more accessible chromatin configuration (ibid).
Molecular dynamics simulations reveal an alternate accessible conformation in which the terminal inter-strand disulfide limits the extent of unfolding and results in a kinked configuration.
Thus we argue that, at least in the fluvial landscape, Nature works through imperfect searches for dynamically accessible optimal configurations.
Second, the concentration of accessible target configurations is lower at low temperature due to the increased stability of tightly packed secondary structures.
For additional security reasons, the partial bit-streams memory locations are only accessible from the configuration controller.
T-Mobile and HTC teamed up to add a few very nice features including one-step e-mail setup for many carriers — Gmail POP is notably absent, but accessible through advanced configuration menus — and a task manager that shows exactly what's running at all times, ensuring you don't have two instances of the Calendar app hogging up precious resources.
