Variant and haplotype level information, however, was readily accessible based on coverage of aligned reads, which we extracted using SAMTools via the Pysam wrapper (http://github.com/pysam-developers/pysam).
The heterogeneity is, in a certain sense, "directly" accessible based on CT Hounsfield Units [ 3].
The system is designed so that health services are accessible based on need regardless of social, locational or financial status.
Within these peptides, 133 sites are carbonylatable (R (20), K (55), P (28) or T (30)) and 86% of them are solvent accessible, judged based on the visual inspection of the crystal structure of human serum albumin (PDB ID: 2I30), whose sequence shares 75% of identity with that of BSA.
A number of financing policies have been developed to guide the provision of effective and accessible healthcare based on the foundations of solidarity, responsibility, equity and transparency.
In this study, we built a concise and accessible CRISPR/Cas9 system based on the pRHV and pRGV vectors.
This program performs analytical calculation of solvent accessible surface area based on the atom coordinates of a PDB file and provides an estimate of the solvent exposure based on the ratio of the side-chain surface area to "random coil" value per residue.
Moreover, a consensus approach combining two methods with multiple models (one based on the accessible surface area and the other on the secondary structure) yielded further improvements.
The classification of a mutation as stabilising or destabilising is made as a consensus of two models, one selected based on the predicted accessible surface area and the other based on the predicted secondary structure of the mutation site.
