They also address some of the challenges of GWAS, such as the high rate of false discoveries, variation between patient cohorts, and accessibility of validation cohorts.
Genome accessibility and haplotype validation.
What will validation validate?
As the technique matures and achieves widespread recognition, validation and accessibility, we believe that antigen receptor profiling will have an impact on many areas of medicine.
As a suggestion the authors should consider community validation Pathway accessibility and distribution is described but it is not clear as to how these models are available in any format except web browsing.
However, the dissemination of new methodologies, such as stochastic or Bayesian, seems to be limited despite their (recent) implementation in software applications (see below) but could also be associated with accessibility, e.g., licensing and validation.
The training programme should be standardised, include objective metrics of validation, offer universal accessibility and provide credentials to confirm successful training [23, 24, 25, 26, 27, 28].
Although new markers (for example, procalcitonin and pro-adrenomedullin) are being evaluated, the swift implementation of these markers is hampered by validation, costs and accessibility.
In the absence of such validation, the MFold accessibility predictions are sufficient to predict the scope of the secondary structure problem in a genome-based array design, even if some details of the prediction are not correct.
Additionally, researchers have yet to compare results from activity space measures to people's perceived accessibility as a means of method validation.
