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This may be explained by the fact that the binding of miR-26a on site II increases the accessibility to site I or, alternatively, binding of one repressive complex on site II may serve as scaffold for attracting cofactors necessary for repression on site I.
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It is more likely that there is a more general disorganisation of the chromatin landscape in the mutant liver and that this allows accessibility to sites that are not accessible to HNF4A.
This suggests that there may be a disorganisation of the chromatin landscape in the TAF4-mutant liver that allows HNF4A accessibility to sites that are not accessible in wild type.
It is more likely that there is a more general disorganisation of the chromatin landscape in the mutant liver and that this allows accessibility to sites that are not normally accessible to HNF4A.
This compaction affects DNA structure and coordinates the accessibility to site-specific nuclear factors during DNA processing events.
Mechanical removal of slash has not been successfully implemented in many areas due to limited accessibility to sites and the high costs associated with collection and transportation of slash.
Owing to limitations of dive time and accessibility to sites on Saba Bank, our survey protocols were designed to efficiently record the habitat characteristics through a combination of quantitative and qualitative measures.
Thus, Sir proteins create a specialized local chromatin structure that exhibits reduced accessibility to site-specific DNA-binding proteins and, by extension, presumably to the transcription machinery.
Horner also warned the team would have to limit accessibility to the site in future, accepting the move would disappoint fans.
Johnson added that "expanding our exposure to potential clients is an essential part of our business and also an ongoing challenge -- and the accessibility to this site helps draw in people who are looking for high-end photos for both residential and corporate arenas.
Of these, the first two also show accessibility to target site both on global folding and regional folding.
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