The phrase "accessibility threshold" is correct and usable in written English.
It can be used in contexts discussing the minimum level of accessibility that must be met for a product, service, or environment.
Example: "The new website design must meet the accessibility threshold to ensure that all users, including those with disabilities, can navigate it effectively."
Alternatives: "accessibility standard" or "accessibility benchmark".
We filtered the results of this exploration to keep only the pairs located on the protein surface as it is the most accessible location for known therapeutic targets (accessibility threshold greater than 25%, using the ASA software [ 26] and implemented by Allan et al. [ 27] based on the 3D PR structure PDB ID 1HSG [ 28] and 3D RT structure PDB ID 1DLO [ 29]).
In order to define the accessibility of the amino acids to some putative external ligand - with a future drug in mind, using the 3D protease structure PDB ID: 1HSG[ 25], we computed the surface accessible to the solvent, using the ASA software [ 51] available at RPBS [ 52], and considered "accessible" all amino acids with an accessibility threshold greater than 25%.
All AAs having an accessibility threshold greater than 25% are considered "accessible".
For a relative accessibility threshold of 25%, only 46.1% of PPIIDSSP are buried while in the case of turns, β-strands, α-helices and coils, 35.8%, 72.2%, 55.4% and 51.9% of residues are buried, respectively.
A solvent accessibility threshold of 25% was used for classifying residues as exposed or buried.
However, these results also suggest an accessibility threshold, above which enzymatic digestibility does not depend heavily on further pore size expansion.
Further discussion on the solvent accessibility thresholds can be found in the next section (Results and discussion).
If cholesterol-sensing proteins bind only accessible cholesterol, then by lowering the cholesterol-accessibility threshold, 25-HC can increase the sensitivity of these cholesterol-sensing proteins by increasing the fraction of cholesterol available to bind to these proteins.
In liposomes composed of 5%25-HC25-HCand10%gisterol, the cholesterol-accessibility threshold increases to 20.3 25.9 mol %, toward the cholesterol-accessibility threshold established for DOPC.
In agreement with previous reports, we found that the cholesterol-accessibility threshold in POPC (with one saturated and one monounsaturated acyl chain) was 41.6 45.0 mol % cholesterol, increased by ∼10 mol % compared with the DOPC cholesterol-accessibility threshold.
We found little change in the cholesterol-accessibility threshold for the 7α-HC-containing liposomes, indicating that only the side-chain oxysterols have significant effects on cholesterol accessibility.
