The t1/2 values of His45 in DHFR-MTX, DHFR-MTX-NADPH and DHFR-folate-NADP+ were lower than apo-DHFR, suggesting that His45 has greater solvent accessibility (ability of bulk solvent to access the particular histidine imidazole ring) in the binary and tertiary complexes than in apo-DHFR.
In order to assess availability of "bulk billing" in general practice, one new item was developed to fit into the scale to assess the availability and accessibility of GP services.
Consistent with the fact that nucleosome-bound DNA is relatively inaccessible to nuclear factors, we observed a low level of RE accessibility surrounding the peak of bulk nucleosomes, relative to RS density.
It can promote the bulk accessibility of electrolyte OH− and diffusion rate within the redox phase.
The properties of the outermost surfaces of porous carbons are critical in determining their functions especially for the accessibility of adsorbate into the bulk pores.
One metric of chromatin structure is accessibility of the DNA in bulk chromatin.
The fast washout of hydrogen from the active sites of the LDM and L6RM, to give a 95 96% yield of deuterium-labeled product, may also reflect an increase in the accessibility of the active site to bulk solvent.
Moreover, an easy mobility and enhanced accessibility of metal ions from the bulk solution to the biomass active sites could also be the possible reason for the maximum biosorption of metal ions at higher temperatures [ 51].
Since the xylan is bulk, for enhance accessibility of active sites of the immobilized xylanase, polyethylene glycol bis amine (PEGA) was used as a spacer for functionalization of GOMNP.
On the other hand, the accessibility of an imidazole group to the bulk solvent has a significant effect on its HDX rate [ 25].
Next, we tested whether the accessibility of nucleosome variants that harbor particular histone modifications or histone variants were identical to that of bulk nucleosomes.
