Sentence examples for accessibility methods from inspiring English sources

Therefore, factors closely related to the accessibility are very relevant to identify and assess the location of urban facilities, which stresses the interest of evaluating accessibility methods.

Second, we predicted sites using conservation of accessibility (Methods).

Indeed we found many more binding sites for deeply conserved miRNAs among the top PITA targets ranked by dG duplex) (39%) and ddG (33%) compared to dG open) (20%) or local AU content (21%), a simple alternative method of estimating site accessibility (Methods).

The proximal end of TMD8 (positions 311 314) was implicated in substrate binding from scanning-cysteine accessibility methods; cysteine replacement of Ser resulted in loss of transport.

While powerful, scanning-cysteine accessibility methods provide only modest detailed information on the roles of individual residues in substrate binding and/or membrane translocation, let alone dynamic structural changes in the carrier that accompany substrate binding.

Once the accessibility method for simulating the tractor-trailer is established, the user can easily apply it to other kinds of mobile construction machinery.

In particular, the substituted-cysteine accessibility method (SCAM) represents a successful example of how to probe transmembrane receptor domains after chemical modification of the mutants with sulfydryl-reacting molecules.

This approach, the substituted cysteine accessibility method (SCAM), has been used to map channel-lining residues in the nicotinic acetylcholine receptor, the GABA receptor, the cystic fibrosis transmembrane conductance regulator, the UhpT transporter, and potassium channels, among others.

Substitution with cysteine changes the sidechain characteristics and also enables study of intra- and extracellular solvent accessibility with membrane-impermeable methanethiosulfonate (MTS) reagents via the substituted cysteine accessibility method (SCAM) [33], [34], [35], [36], [37].

Several studies that use serial deletions and co-immunoprecipitation [28], substituted cysteine accessibility method [13], [29], [30] or electron microscopy-based analyses [31] reported that PS1/γ-secretase may form a ring-like pore within the hydrophobic environment of a membrane.

This binding mode is consistent with site-directed mutagenesis studies and substituted cysteine accessibility method (SCAM) data and retains the amine placement seen in the LeuTAa structure.