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Discover LudwigThe phrase "accessibility exposed" is not standard in written English and may cause confusion.
It could be used in contexts discussing the visibility or awareness of accessibility issues, but it lacks clarity.
Example: "The report highlighted how accessibility exposed the challenges faced by individuals with disabilities in public spaces."
Alternatives: "accessibility revealed" or "accessibility highlighted".
Exact(1)
High solvent accessibility (exposed nature of residues in complexed form) and moderate/less conservation of these residues could be the possible reason why these residues could not be predicted by any of the available methods for hotspot prediction.
Similar(58)
As demonstrated in earlier work, increases in cholesterol accessibility expose cholesterol to cytosolic acceptors such as cyclodextrin or apolipoproteins, providing a possible mechanism for how 25-HC could enhance intracellular cholesterol trafficking or elimination of cholesterol from the cell.
Therefore we adopted six physicochemical-property-based features, namely hydrophilicity, flexibility, accessibility, polarity, exposed surface and turns to predict solvent accessibility [ 45].
The prediction was carried out with the aid of physico-chemical parameters, such as hydrophilicity, flexibility/mobility, accessibility, polarity, exposed surface, turns, and antigenic propensity [ 27].
Such colocalization may crucially depend on the accessibility of exposed grooves, which are rich in aromatic residues, on the surface of amyloid fibrils [ 5].
For solvent accessibility: buried or exposed to solvent, as predicted by ACCpro [36].
This enables the cellulase accessibility to cellulose exposed by the action of the adjacent xylanase.
It can be clearly seen from Figure 5(a) that the number of two types of solvent accessibility (buried and exposed) was equal.
The SASA ratio is the Residue Solvent Accessibility divided by the residue solvent accessibility of the fully exposed His residue, calculated using an in situ tripeptide Gly-His-Gly model.
ATAC-Seq and RNA-Seq analyses show pronounced changes in chromatin accessibility of PAEC when exposed to shear stress, which relate to altered gene expression profiles.
When analyzed in detail, it was observed that all these residues contributed more energy than an average interface residue (normalized energy per residue was greater than 1), but they were found to be exposed (solvent accessibility more than 7%) in the complexed form.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com