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Currently, most researchers compare their chromatin accessibility data to other published datasets.
PWMs can perform well in practice: these models have been combined with chromatin accessibility data to successfully predict where specific TFs bind across the genome in a cell-specific way (Kaplan et al., 2011; Pique-Regi et al., 2011).
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The three basic principles of information security, generally known as CIA, are confidentiality (no unauthorized disclosure of data), integrity (no unauthorized modification of data), and availability (ensuring the accessibility of data to legitimate users).
When discussing scientific value in online data sharing platforms, we are referring to the need for quality, quantity and accessibility of data to be of sufficient standard to allow morally responsible data sharing.
In particular, there is a need to improve the accessibility to data sets, to standardise the data sets, to promote communication and harmonisation of programmes and to incorporate the flexibility to change monitoring protocols to amend the chemicals under investigation in line with changing needs and priorities.
Integration of DNA accessibility data allowed us to reconstruct transcriptional networks controlling photoreceptor differentiation.
The accessibility data were used to construct a topology that was in agreement with the standard model.
The ability to derive residue-specific solvent accessibility data that might be used to complement structural constraints from SS-NMR studies demonstrates that HRF with single-amino acid resolution may be valuable for the analysis of other fibrillar and oligomeric forms of Aβ40, especially when sample quantities are at a premium.
According to our accessibility data, an aqueous/hydrophobic boundary in helix-III is near G109 and I133.
However, according to the accessibility data of the buried residues in the membrane bilayer, most of mutants showed a slow reaction rate with 4-PDS within membrane bilayer (Figure 6B and Table 2).
To obtain the solvent accessibility data required for our analysis, we mapped all sequences to homologous sequences with known structure in the PDB, and discarded genes for which we could not find any reliable structure information.
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