Sentence examples for accessibility and conservation from inspiring English sources
Two human monoclonal anti-HIV-1 antibodies, 2F5 and 4E10, were utilized to investigate the accessibility and conservation of gp41 MPER epitopes on five different clades of HIV-1 in the absence and presence of sCD4.
Global Crop Diversity Trust - @Croptrust Global Crop Diversity Trust ensures the accessibility and conservation of crop diversity that protects food security.
(ii) All polar residues in the 131 family set, regardless of solvent accessibility and conservation but where the polar residue forms a hydrogen bond to a mainchain atom group.
If the association between residue accessibility and conservation level is strong enough, it might be used to differentiate between correct and incorrect model structures, as incorrect structures are unlikely to feature this pattern by chance.
Different miRNA-target prediction algorithms predict targets with different techniques and criteria including base pairing, target accessibility and evolutionary conservation of target site.
Most approaches for miRNA target identification rely on either one or a combination of seed matching, site accessibility and phylogenetic conservation [ 1].
Another recent structure-based prediction method [ 49] is based on various centrality measures of nodes in graphs of interacting residues: closeness, betweenness and page-rank centrality, general center of mass of the structure, relative solvent accessibility, and sequence conservation.
However, since these tools are based on certain assumptions (e.g., base complementarity in the 3′UTR, thermodynamic stability, target-site accessibility, and evolutionary conservation of miRNA binding sites), their predictions are accompanied by large numbers of false positives.
Four of the amino acids (two histidines and two glutamic acids, positions indicated in Fig. 1 as black boxes) present within the cleft have been proposed to form an active site of undefined activity due to their location, surface accessibility and evolutionary conservation [ 29].
PPCheck was applied on an earlier studied dataset 26 of well characterized 270 protein protein complexes in order to select the optimum values of solvent accessibility and number of conserved residues (conservation score ≥0.65) present at the interface, which can help in clear differentiation of native-like poses from the non-native-like ones.
In particular, mCarts is an algorithm based on a hidden Markov model that predicts functional RBP binding sites based on the number and spacing of motif sites, accessibility (RNA secondary structure) and conservation information.
