Vaccine effectiveness varies considerably depending on study population (age, associated diseases, number of vaccine doses, and access to vaccine), specificity of outcome (medically attended acute respiratory tract disease, laboratory confirmed influenza, pneumonia associated admissions to hospital or deaths, or seroconversion to circulating influenza virus strains), and circulating strains.
As a result of this difference, chemical proteomics can use tissue extracts acquired from diverse sources, including human subjects, which is otherwise only possible in those rare cases where one has access to high-specificity and high-affinity antibodies.
This includes lack of access to clones of desired specificity and problems of variable levels of production where clones are available.
At present, however, we can not exclude that some of the CD4+CD28null T cells with access to the joint have specificity for cartilage-derived and/or citrullinated candidate antigens.
8 This is driven by a lack of access to time-critical high-specificity biomarkers of infection in critical care 9 where overwhelming systemic inflammation of the body is a common occurrence and is often not caused by infection (it may, eg, be caused by trauma, blood transfusion, pancreatitis).
"[The MAL is] a kind of thinking device in that providing access to the utterly unique, material specificity of these computers, their interfaces, platforms, and software makes it possible to defamiliarize or make visible for critique contemporary, invisible interfaces and platforms," says a statement of purpose at MAL's website.
Excluding children without routine access to health care enhances the specificity of the diagnosis of ADHD, but it also likely underestimates the total number of ADHD cases that are attributable to prenatal ETS exposure and environmental lead exposure.
The mite displays high host specificity and requires access to colonies of Apis spp. to complete its lifecycle.
Arguing, inter alia, that requests for access to archives reveal logical inconsistency with specificity requirement.
The expectation is that single target molecules with high specificity might not have access to complex interacting neural pathways, and that moderate potency could engender fewer off-target side effects.
