Exact(18)
"I've got an expert sitting next to me who can access pathways I can't.
How do you actively create access pathways and, as numbers increase, encourage agents to put Eastern Asian actors forward not just for racially specific roles, but all types of roles?
Instead, it is conceivable that different therapeutic profiles are caused by different mechanisms of action, such as different binding sites, different access pathways to the binding site [4] and different state-selectivity [5].
The pKa value nevertheless is a major determinant of which access pathways to the binding site are passable for the drug, and thus has been shown to affect onset/offset kinetics and use-dependence [4], [20], [21].
First, they utilise several access pathways to the service.
Substrate access pathways, which often incorporate molecular gates, impose additional constraints on ligand binding to the active site.
Similar(41)
First, we predicted an oxygen access pathway in Aerococcus viridans LOx (AvLOx) based on its crystal structure.
Cable modems, the newest higher-speed access pathway, only promise 500 kilobit throughput 4 times ISDN, but still far short of the satellite broadcast data stream required for MPEG2.
The Expedited Access Pathway was designed as a new program for medical devices that demonstrated the potential to address unmet medical needs for life threatening or irreversibly debilitating conditions.
In comparison, the axes of the two helices from the linker to the C-terminus (helices 2 and 2′) are wider apart from each other, creating a lateral access pathway around K47 from the aqueous phase to the center of the designed hydrophobic core.
Whereas halothane produces minor changes in the monomer structure, the quaternary arrangement of the dimer is shifted by about half a helical turn and twists relative to each other, which leads to the closure of the lateral access pathway to the hydrophobic core.
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