Exact(8)
The well-characterized internationally accepted validation principles for creating validated models have been used by regulatory agencies of United Sates (US) and gaining a boost in the European Union (EU) too [8, 11 13].
The validation process according the accepted validation plan was performed by an outside contractor according to valid standards (methods, calibrations of the measurement equipment and documentation).
Following accepted validation procedures, analysis involved empirically evaluating the reliability, dimensionality, and validity of this new tool before its distribution for more applied usages (Netemeyer et al., 2003; Bachman, 2004).
The goal of this study is to participate in design of a consistent and hopefully widely accepted validation terminology and methodology for themes which relate Computer-Assisted Radiology and Surgery (CARS).
We have also shown that many gene probes that best correlate with the divergence of the normal tissue profile have been identified as useful biomarkers (via other accepted validation methods).
Establishing a widely accepted validation instrument is technically difficult, but more so in an emerging field such as mobile telephone epidemiology.
Similar(52)
The reference dataset was used as the hypothesis generating dataset, and all pathways with a FDR adjusted p-value < 0.1 were accepted for validation in the independent validation dataset.
Only validated clinical interviews or questionnaires were accepted, but validation in each ethnic group was not required.
It will be necessary to further validate these findings with additional independent cohorts of samples to meet accepted international validation guidelines [ 55].
It is widely accepted that validation in independent cohorts, from those in which a model is originally derived, is a mandatory step in the development of prognostic methods.
Several previous studies from both microarray and high-throughput sequencing data have shown that 95% of the primer sets surrounding random selected regions of the genome displayed ΔCp values of less than two, and a threshold of ΔCp > 2 has been generally accepted for validation of DHSs, as ΔCp > 2 in principle reflect a four-fold reduction in DNA concentration [ 3, 4].
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