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Beta blockers are now a widely accepted therapy for heart failure.
Cryotherapy, the application of low temperatures, is the most widely accepted therapy at this time.
It is ethically difficult for doctors to construct a study in which patients forgo an accepted therapy that works and has been proved, no matter how traumatic it is.
Treatment with steroids for short term cluster headache (CH) prophylaxis is a widely accepted therapy.
Liver transplantation has become a widely accepted therapy for the management of the complications of cirrhosis and liver failure.
Although DBS is a widely accepted therapy in motor disorders, it remains an invasive and expensive procedure.
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38– 40 Unfortunately, the cost of new preferred therapies compared with previously accepted therapies may represent a barrier to a broad acceptance of clinical guidelines.
Myofascial trigger point (MTrP) injection and trigger point dry needling (TrPDN) are widely accepted therapies for myofascial pain syndrome (MPS).
With regard to survival time, the regulatory agencies will demand OS as a primary endpoint if the substance to be tested is probably more toxic than the comparator, if no accepted therapies are available for further treatment and if the time from disease progression to death is short.
This is perhaps the most challenging question and may well require novel therapies in addition to aggressive adoption of currently accepted therapies.
Nonetheless, the data show that teriparatide is at least as efficacious as other accepted therapies for osteoporosis.
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CEO of Professional Science Editing for Scientists @ prosciediting.com