Although its safety and efficacy are widely accepted, the effect of GL on HMGB1 expression in sepsis or endotoxemia as well as the underlying molecular mechanism has not been reported up to now.
Turing accepted hormone treatment as an alternative to imprisonment, and it is generally accepted that the effects of this led to him killing himself in 1954.
It is now generally accepted that the effects of ROS result from direct or indirect responses of sensing systems involving antioxidants, rather than from oxidative damage to bio-molecules.
By hypothetical reasoning, it is usually accepted that the effects of lactic acidosis may overlap with those of metabolic acidosis.
It is generally accepted that the effects of APP mutations on Aβ generation and aggregation can be accurately modeled by overexpression of mutant APP in cultured cells or transgenic mice; however, this is less evident for PSEN mutations.
Although it is generally accepted that the effects of 13cisRA are mediated by isomerisation to the more transcriptionally active all- trans or 9- cis isomers (Armstrong et al, 2005a), this does not account for all pharmacological effects associated with the use of this retinoid (Blaner, 2001).
It should be reiterated that the beguiling idea that α-sheet is the material of the prefibrillar intermediate responsible for such alterations to membranes is not yet generally accepted, but the effects of what may be an earlier type of membrane, whatever its molecular nature, on present-day membranes are clearly of interest.
While the disastrous effects of high dose ionising radiation (HDIR) is well known and accepted, the detrimental effects of low dose radiation is not well understood and has been a topic of much debate.
Therefore, while the relation between higher tidal volume and VILI is robust and largely accepted, the protective effects of PEEP are not so widely agreed.
Today's Republicans are less likely than they were a decade ago to accept that the effects of global warming have begun, that humans are responsible, and that there is a scientific consensus on these questions.
