It is now commonly accepted that the genetic influences on much of human disease is not Mendelian in nature but is genetically complex (Altshuler et al. 2008); however, identification of the genetic determinants in genetically complex disorders has been elusive, a problem referred to as "missing heritability" (Queitsch et al. 2012) or "phantom heritability" (Zuk et al. 2012).
Kelly said even if you accepted that fiddling with "the CO2 knob" could influence climate change, he had doubts that countries could meet their Paris commitments "without a technological breakthrough".
It is generally accepted that the DNA sequence influences, to some extent, in vivo nucleosome positioning, which is regulated by many other additional epigenetic factors.
It has long been accepted that the secreted factors influencing muscle cell regeneration in vivo are largely of immune cell origin; indeed, immune cells have been reported to reach concentrations over 100 000 cells/mm in regenerating muscle tissue.
It is broadly accepted that the interpretation criteria might strongly influence the prognostic value of UroVysion results.
Christian, Jewish and Islamic influences were added later, though the Alevi accept that the Islamic influence is the strongest.Their number is uncertain, because no census in Turkey has asked about religious affiliation since the early 1920s.
The use of topographic patterns has been a continuously growing area of research for tissue engineering and it is widely accepted that the surface topography of biomaterials can influence and modulate the initial biological response.
Furthermore, it is well accepted that the biosynthetic activity of chondrocytes is influenced by the mechanical environment.
Pain scoring was retrospectively based on the patient's untreated migraine attacks in the 3-month period prior to recording and therefore it was accepted that the pain score recorded was not influenced by medication effects.
