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Acceptance of submissions with higher-than-threshold ICERs varied by HTA agency and was not significantly influenced by disease category.
The acceptance of submissions with ICERs higher than the threshold was assessed across different agencies and across indications, in order to inform future reimbursement submissions.
10 While the agencies included in this analysis all use cost-effectiveness criteria to inform decision-making, in-depth review of individual submissions suggests that demonstration of clinical benefit can be a contributing factor to the acceptance of submissions for which standard cost-effectiveness criteria are not met.
AUT assisted with the concept of the GAPS community of practice, the implementation of the forums, the financial oversight of the project, the acceptance of submissions to the online community of practice, the organization of the online resources for the community of practice, writing and submission of the project report and creation of analysis framework for the analysis team.
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We hypothesized that no significant differences in acceptance rates of submissions with ICERs higher than the threshold are observed between disease areas.
No significant differences in acceptance rates of submissions with ICERs higher than the threshold by disease area were observed in the pooled analysis, based on the funnel plot and chi-square test output.
It has been suggested that clinical significance, clinical and economic uncertainty, relevance of endpoints, indication (specifically, drugs for life-threatening conditions), and cost to government (in terms of financial impact) can affect the likelihood of acceptance of PBAC submissions, in addition to cost-effectiveness criteria, 23, 25– 27 which may influence the decision-making process.
PRL currently accepts about 35% of submissions, and the median time to acceptance is more than 4 months, says editor Stanley Brown from his office in Ridge, New York.
This suggests the JAMA policy affected the number of submissions, the acceptance rate, or both.
The only time recorded by the AMT system is HIT completion time (the time from acceptance of the HIT to submission of the HIT), which can be used for participant rejection.
A statistics of submissions and final acceptances by countries is shown in Additional File 2. The manuscript revision and re-review policy of InCoB/ISCB-Asia 2011 resulted in a more than twofold greater acceptance rate compared to ISMB/ECCB 2011 [ 6] which considers only manuscripts requiring minor revisions.
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