Sentence examples for acceptable surrogate for from inspiring English sources
It also proved an acceptable surrogate for biomechanical testing, confirming that a lateral lumbar interbody cage and plate construct reduces ROM to a similar degree as anterior lumbar interbody cage and plate constructs.
Importantly, in a study using 86Y-DOTATOC PET as the gold standard for measuring renal residence times for 90Y-DOTATOC, Helisch and co-workers concluded that 111In-pentetreotide was a reasonable and acceptable surrogate for 90Y-DOTATOC when assessing individual patient pre-therapy renal dosimetry [35].
Still, PPV should be an acceptable surrogate for stroke-volume variation in this type of comparison.
These analyses provide only modest support for considering PFS as an acceptable surrogate for OS in patients with advanced NSCLC.
Our analyses provide only modest support for considering PFS as an acceptable surrogate for OS in patients with advanced NSCLC.
Therefore, the predicted pharmacokinetic profile based upon the in vitro release kinetics is an acceptable surrogate for the conventional animal test.
In these cases, measuring covariates that are closely connected (on drug disease cycle) to the clinical response may provide acceptable surrogate information for clinical decision making.
Our analyses suggest that PFS is not a statistically acceptable surrogate endpoint for OS in patients with metastatic NSCLC treated in first line with docetaxel-based or vinorelbine-based chemotherapies.
In some instances, protein intra-cellular movements or translocations observed during signal transduction have been considered an acceptable surrogate to screen for inhibitors of protein-protein interaction, which is playing a key role in cell signaling [ 114, 115].
In the present study, during which hemodynamic conditions were constant, changes in PaO2 were acceptable surrogates of recruited volume.
Product development for treatment of localized prostate cancer has been stymied by the impracticality of using overall survival as an endpoint in patients with localized disease and the lack of acceptable surrogate endpoints.
