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Our group has recently disclosed medicinal chemistry efforts to identify highly potent, orally bioavailable selective orexin 2 receptor antagonists (2-SORAs) that possess acceptable profiles for clinical development.
The various low-angle reflections on the smectic layers were used to evaluate the projections of the electron density profiles along the layer normal, and the most physically acceptable profiles were selected from the numerous possibilities for each smectic mesophase.
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The safety variables included in the extension study also indicated an acceptable profile for dienogest.
Compound 2i also showed acceptable PK profiles.
All treatment regimens showed acceptable tolerability profiles.
Both vaccines are immunogenic and show clinically acceptable safety profiles.
Both vaccines were well-tolerated and had clinically acceptable safety profiles, as reported previously.
Both treatment regimens (aclidinium 400 μg bid and tiotropium 18 μg od) had acceptable safety profiles.
16 Hence, acceptable safety profiles and outcomes (decreased surgeries and hospitalisations) have not been demonstrated in this subgroup of patients.
7 9 These H5N1 vaccines were highly immunogenic and had clinically acceptable safety profiles in children aged ≥6 months and adults.
Nintedanib is well tolerated and has an acceptable safety profile.
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CEO of Professional Science Editing for Scientists @ prosciediting.com