Sentence examples for acceleration of onset from inspiring English sources

This phenotype is primarily due to the acceleration of onset of chondrocyte hypertrophy and, as a consequence, inappropriate endochondral mineralization.

It is hypothesized that in utero and early childhood exposures to EDs may be responsible, at least in part, for decreases in semen quality; increasing incidence of congenital malformations of the reproductive organs, such as hypospadias; increasing incidence of testicular cancer; and acceleration of onset of puberty in females.

Yet, when Caspase-2 deficiency was combined with haplo-insufficiency for p53, no further acceleration of disease onset was observed, indicating that loss of heterozygosity that usually accelerates disease onset in Eμ-Myc/p53 +/− mice is dominant over loss of Caspase-2 in Eμ-Myc-driven lymphomagenesis.

As loss of Caspase-2 leads to an acceleration of tumor onset in the Eμ-Myc mouse lymphoma model, whereas loss of Pidd1 actually delays onset of this disease, we set out to interrogate the role of Raidd in cancer in more detail.

Anti-GITR-treated mice showed acceleration of disease onset reaching 100% of diabetes incidence by 9 weeks of age.

Treatment of 10-day-old non-obese diabetic (NOD) mice, which spontaneously develop diabetes, with an agonistic GITR-specific antibody induced a significant acceleration of disease onset (80% at 12 weeks of age).

Using another agonistic anti-GITR antibody, 2F8, we found a very significant acceleration of disease onset following a short treatment course (3 injections, once a week) started in young mice (10 days of age).

Although our results suggest IA regulation as a primary factor in intrinsic plasticity, other mechanisms may also contribute, as preventing endocytosis did appear to completely abolish the pairing-induced acceleration of AP onset time (Figure 6).

We have previously shown that nutritional deficits and excesses during intrauterine, lactational and post-weaning periods resulted in the acceleration of pubertal onset and subsequent changes in ovarian function [5].

The acceleration of anaphase onset in mad2+/− oocytes may not seem very striking at first sight as meiosis I is very long and takes around 9 hours from GVBD until PBE.

In contrast, the lower dose resulted in a slight acceleration of puberty onset in male rats compared with controls (p < 0.1).