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Finally, we show that a knockdown of CN levels in Xenopus oocytes results in a decrease of protein synthesis inhibition and a rapid acceleration of apoptosis.
Factors other than impaired phagocytosis by macrophages, as proposed in this study, that may contribute to elevated apoptotic cell count in the diabetic wound include acceleration of apoptosis caused by advanced glycation end products (AGEs), activation of protein kinase C (PKC) and increased oxidative stress [34].
14 and 19 was due to acceleration of apoptosis.
We also demonstrated that IDR-E804 effectively suppresses the growth of CT-26 colorectal cancer grafts via inhibition of angiogenesis as well as acceleration of apoptosis.
Although less potent than JQ1 or I-BET-762, I-BET-151 showed marked acceleration of apoptosis and perturbation of growth in primary cells obtained from patients with mixed lineage leukemia (MLL).
We also observed a reduced expression of factors involved in DNA replication initiation, which correlates with an enrichment of cells in the G1 phase of the cell cycle as well as an acceleration of apoptosis.
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This suggests that acceleration of neutrophil apoptosis could be beneficial in the treatment of ARDS.
Similarly, no acceleration of neutrophil apoptosis was observed in diabetes-induced dogs [ 25] and rats [ 37].
HK attenuates the severity of AP and lung injury by acceleration of acinar cell apoptosis.
At the molecular level, this involves occupancy of discrete RPB-Jκ binding element(s) in the survivin promoter upon Notch activation, which results in transcriptional upregulation of survivin levels, inhibition of apoptosis, and acceleration of mitotic transitions selectively in ER-negative breast cancer cells [ 35].
Also, HIF-1α-deficient chondrocytes showed an acceleration of catabolic stress-induced apoptosis in vitro.
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