However, most components of the secretory phenotype promote cancer progression by enhancing survival, migration, invasiveness, and angiogenesis, accelerating cell repopulation, altering epithelial differentiation and causing epithelial-mesenchymal transition (EMT, e.g. IL-6, IL-8 and recently reported WNT16B and SPINK1).
These include dose escalation using interstitial brachytherapy (IB) with conformal EBRT, accelerated or altered fractionation, and radiosensitization with the addition of chemotherapy.
Brunekreef and Holgate (2002) hypothesized that air particles increase the risk of cardiopulmonary mortality through direct and indirect pathophysiologic mechanisms, including pulmonary and systemic inflammation, accelerated atherosclerosis, altered cardiac autonomic function, and increase of inflammatory cytokines in the heart.
In diabetic rats, the glycolytic metabolism and the protector effect of glutamine on neutrophils is altered, accelerating apoptosis and increasing susceptibility to infections [ 23].
While the legal industry had begun to face the need for change before the current economic downturn, the crisis is accelerating trends that will alter the structure and operations of law firms going forward.
"We hypothesized that these may be responsible for the accelerated change, by altering the internal dynamics and energy of the Great Red Spot".
In addition to accelerating tumorigenesis, telomere dysfunction dramatically altered the spectrum of tumor types in p53+/- mice.
Changing human land use is accelerating global element cycling and appreciably altering ecosystems in the riverine estuarine systems.
Fibre addition promoted the crystallization of PLA by favouring the heterogeneous nucleation and accelerating the crystallization kinetic, without adversely altering the thermal stability.
Adjacent co-adsorbed water molecules participate in the transition state of formate decomposition, accelerating the formate turnover rate and altering the selectivity to favor dehydrogenation.
