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We have recently shown that the presence of penile HPV is associated with delayed regression whereas condom use revealed accelerated regression (Bleeker et al, 2003).
This may furthermore explain the accelerated regression of GLV-1h255 infectumorsmors, as higher titers could result in an increased oncolysis, which has been shown to be an important factor for the therapeutic efficacy of VACV [ 27].
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In pupillary membrane vessels, which naturally regress during development, it has been shown that blocking VEGF function accelerates regression [19].
In the single-regression study published, Moore's group demonstrated that 4-week treatment with 2′F/MOE anti-miR-33 oligonucleotides accelerated the regression of atherosclerosis in Ldlr−/− mice with established atherosclerotic plaques (Rayner et al, 2011b).
Depression in AD is associated with accelerated cortical regression and white matter atrophy, particularly in frontal and temporal areas.
The AKTi combined with Ful, however, significantly accelerated tumor regression compared to Ful alone, with median time to tumor halving of 12 days and 35 days, respectively.
We confirmed that the degradation of collagen IV facilitated viral infection of the tumor tissue, represented by significantly higher viral tumor titers and an accelerated tumor regression.
Where non-normality could not be resolved by log-transformation, 95% CIs were estimated using semi-parametric bias corrected and accelerated bootstrap regression with 1,999 resamples.
Taken together, these results indicate that a GLV-1h255-mediated GLV-1h255-mediated GLV-1h255-mediated9 leads to a degradation of collagen IV, facilitating intra-tumoral viral dissemination, and resulting in accelerated tumof regression.
Although the levels of PTEN and the antiestrogen used dictated the extent of the response in vitro, the in vivo combination of fulvestrant with an AKT inhibitor significantly accelerated tumor regression (three-fold) compared with either inhibitor alone.
Therefore, 95% CIs were calculated using the semi-parametric bias corrected and accelerated bootstrap regression method (with 1,999 resamples) bResults are expressed as ORs cAdherence defined as a score of >23/25 on the MARS questionnaire Table 4 shows the baseline and follow-up anthropometric, clinical and biochemical measures.
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