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The aortic allografts develop excessive chronic arterial wall inflammation and neointimal hyperplasia with accelerated plaque growth by the end of 4 weeks.
The current results therefore point to another potential mechanism by which Cav-1 may prevent plaque growth and destabilisation: expansively remodeled lesions may hide accelerated plaque growth with formation of large lipid pools with massive inflammatory response and protease activity that remains clinically silent and untreated for a long time.
Excess inflammatory cell infiltration and neointimal hyperplasia (accelerated plaque growth) were detected in aortic allograft transplants at 4 weeks follow up in control, saline treated, wild type (WT) mice, using either C57Bl/6 donor to Balb/c recipient mice (Fig. 1A,E) or Balb/c donor to C57Bl/6 recipient mice (Fig. 1 C, E, n = 19).
Although both C57BL/6J and apoE−/− mice maintained on the HC diet, which results in accelerated plaque development [21], [39], [40], exhibited increases in plasma arginase and reductions in global arginine bioavailability, the apoE−/− mice fed the HC diet were the only animals with increases in tissue arginase activity and expression.
24 It may also indicate accelerated plaque growth.
Even after correction for traditional risk factors, patients with chronic inflammatory disorders have accelerated plaque progression [ 3].
Similar(46)
EC-specific overexpression of YAP accelerates plaque formation.
Kraft, A. W. et al. Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice.
To enhance and accelerate plaque formation, ApoE KO mice were fed a high-fat diet.
To investigate whether additional replacements could accelerate plaque formation in this virus, populations V19 4A and V19 4B at passage 2 (depicted in Table 1 and Figure 3) were subjected to 25 additional passages in BHK 21 cells.
Unlike butadiene inhalation, acrolein inhalation did not accelerate plaque development.
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