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The data thus are very much as would be expected from accelerated mutation and substitution rates within primate lineages.
Central to Goodman's research agenda was his argument for a link between accelerated mutation rates and functional innovations in the anthropoid molecular structure of cytochrome c.
The latter is in keeping with the lack of excess genomic instability in the Xpd mutant mice [31], which is in striking contrast to the situation in Xpa null mice in which an accelerated mutation accumulation has already been observed before 10 months [32].
On the other hand, an accelerated mutation rate equal to that of fast-evolving human mitochondrial DNA [26] yielded age estimates of 139.91±10.09 Kya for rs6556547, 113.31±18.35 Kya for rs187269, 92.82±19.06 Kya for rs1816071, and 69.44±20.14 Kya for rs1816072 in coalescence-based calculations with the Rho index [27] (Table S6; Figure 4).
Machado [ 104] found that species of Ceratosolen exhibited accelerated mutation in their mitochondrial genome relative to species in other genera.
The accelerated mutation rates associated with the cyclic peptide domains could reflect either a strong positive selection or specific hypermutation.
Similar(38)
Mutator phenotypes should therefore be thought of as carcinogenic because they accelerate mutation production during tumorigenesis.
It is based on steady-state genetic algorithm (GA) and adopts shift registers for accelerating mutation and crossover operations while reducing area cost.
We believe that the combination of the NM-CGH microarray followed by exome sequencing will accelerate mutation detection and improve the diagnostics of NM and related disorders.
Two basic mechanisms are known to accelerate mutation in bacterial strains: a loss of DNA repair or proofreading systems and the induction of pro-mutagenic pathways.
Even Magneto's plan in the original (temporally later) X-Men movie, to mutate humans by force, is similar to Shaw's plan to accelerate mutations in humans through nuclear war, with both eerily reminiscent of Nazi experiments on Jews.
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