SAR from the indazole series led to the design of a pyrazolo[4,3-b]indole core and accelerated knowledge-based fragment growth resulted in potent and efficient MetAP2 inhibitors, which have shown robust and sustainable body weight loss in DIO mice when dosed orally.
In this paper we propose a coupling between two knowledge based methods: Case Based Reasoning and Constraint Satisfaction Problem to accelerate preliminary design by on line knowledge acquisition during problem solving episodes.
As labor becomes more knowledge based and communications technology advances, the division of labor accelerates.
Transitioning knowledge based services, and the multiplier impact that technology has on culture, politics and human development, only accelerates discontinuous change.
The knowledge based on an economy defined by Campbell and Carayannis (2014) is a process of economic learning to catalyze and accelerate the sustainability of economic growth.
Science is knowledge based on hypothesis, experimentation and observation.
Is our knowledge based on multicultural research?
These devices can expedite job-related training and accelerate knowledge transfer.
Real-time systems also help to build social bonds and accelerate knowledge sharing.
Iressa had been given accelerated approval based on its ability to shrink tumors.
To the best of our knowledge, no method accelerates recognition based on the GSM.
