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A unifying trend of accelerated glucose consumption just before and during MnP production was observed in these batch cultivations (Figure 1A & 1B).
Although accelerated glucose consumption and lactate production was detected only at the early time points by the transfectant encoding the shorter PFK-M fragments, the data suggested the important role of the modified human PFK-M on de-regulated metabolic flux through glycolysis.
The bitransgenic tumours also have an accelerated glucose metabolism.
A key hallmark of many aggressive cancers is accelerated glucose metabolism.
Malignant cells are known to have increased glucose uptake and accelerated glucose metabolism.
The consequence of cancer cell-specific glycolysis is the accelerated glucose consumption and continuing supply of building blocks of amino acids, fatty acids and nucleotides.
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As previously observed [20], the incorporation of radiolabeled glucose into total lipids decreased by ∼20% in stable SCD1-knockdown A549 (hSCDas) cells (Figure 4C), confirming that the presence of a fully active SCD1 is crucial for sustaining the accelerated glucose-mediated lipogenesis in cancer cells.
Herein, various nanomaterials were designed as catalysts to accelerate glucose oxidation reaction.
Either demand for ATP or energy starvation would accelerate glucose consumption rate.
A constant high rate glucose infusion is expected to accelerate glucose turnover and the overall system response [ 34].
Another key enzyme involved in glycolysis that may accelerate glucose metabolism in cancer cells is pyruvate kinase type M2 (M2-PK).
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