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The accelerated expression of differentiation markers for all three germ layers resulting from Oct4 knockdown confirms that this method has no detectable adverse effects that limit the range of differentiation.
This short lifespan is coupled to fast growth and accelerated expression of age-related phenotypes [2], [7].
A laboratory inbred strain of the annual fish Nothobranchius furzeri shows exceptionally short life expectancy and accelerated expression of age markers.
In addition, accelerated expression profiles associated with AD and FTLD suggest some common mechanisms underlying the risk of developing these diseases.
Finally, we observed shorter lifespan and accelerated expression of age-related markers in the inbred laboratory strain compared to these wild-derived lines.
In vitro targeting of the resolved triad in embryoid bodies accelerated expression of Nkx2.5, Mef2C and cardiac-MHC, enhanced beating activity, and augmented cardiogenic yield.
Similar(31)
An alternative pathway, one involving two evolutionary steps, can theoretically accelerate expression of gene 1 and thus provide a fitness advantage.
The Ahr/Arnt heterodimer binds to the small conserved promoter elements XREs, also termed dioxin-responsive elements (DREs), which recruits cofactors (p300, cAMP, CREB, and RIP140) to accelerate expression of the responsive genes [ 29].
miR-143 and also miR-103 can induce adipogenesis in 3T3-L1 andpocytes augmentment or accelerate expression of several key adipogenesis-regulated genes, such as FABP4 and adiponectin [ 27].
In the other hand, BMP5 accelerates expression of hypertrophy markers which is of relevance in both development and diseases such as osteoarthritis [ 20], this is consistent with the presence of higher values in OA patients macerates against OP ones.
It was reported that GATA-2 directly activated GATA-1 expression in early erythroid progenitors, and then GATA-1 accelerated its expression after its own expression has been initiated [ 20].
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