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Smith, A. D. et al. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial.
5. Smith AD, et al. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial.
Our principal finding is that among the 722 MS subjects with MRI data, those bearing the PCK1 allele associated with AD susceptibility may have greater or accelerated brain atrophy.
Since accelerated brain atrophy is a characteristic of subjects with mild cognitive impairment who convert to Alzheimer's disease, trials are needed to see if the same treatment will delay the development of Alzheimer's disease.
Thus, our statistical power is limited in addressing this question, and we cannot yet distinguish whether the effect of the PCK1 locus is one of accelerated brain atrophy in the context of MS or whether PCK1 affects the maximal BPF attained in the course of brain development.
The mechanisms underlying accelerated brain atrophy in diabetic patients are less clear.
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The new and improved accelerated brain.
For example, does music training accelerate brain maturation?
The accelerated rate of brain atrophy in elderly with mild cognitive impairment can be slowed by treatment with homocysteine-lowering B vitamins.
We show that a simple and safe treatment that targets homocysteine can slow down the accelerated rate of brain atrophy found in mild cognitive impairment.
The accelerated trajectory of brain atrophy we observed is in keeping with a progressive neurodegenerative process triggered by the injury.
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