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Furthermore, our study provides the scientific foundation for further fundamental investigations in model systems, which may accelerate validation of OPN and/or coregulators as molecular targets for therapy.
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These limitations are discussed with an indication of future developments that will accelerate the validation of data generated when completing a molecular characterization of disease pathogenesis in cattle.
Develop tools for ortholog prediction between rice, Arabidopsis and crops to accelerate candidate validation and information transfer.
These putative sites provide a guide to accelerate experimental validation experiments.
Altogether, this study provides a model to accelerate the validation of potential biomarkers on the translational journey to the clinic.
In summary, this GWAS study has identified new sources of Pst resistance and provided closely linked markers to accelerate their validation and deployment in wheat breeding programs.
Several reports has thus described construction of cassette-type vectors for rapid conversion of phage-displayed antibody fragments into whole IgG or scFv-Fc format to accelerate the validation process that is done under in vivo conditions closely mimicking those expected to occur with therapeutics and imaging agents [ 3- 5].
Goldstein said the program is structured to provide startups with an increased ability to achieve accelerated market validation within 90 days.
While open access chemistry was met with a lot of skepticism 5 years ago, the success of freely available probes in accelerating target validation and discovery of new biology has spurred many open access programs in the pharmaceutical industry.
One strategy to accelerate target gene validation in mouse models is to apply the CRISPR/Cas system in zygotes for the one-step generation of animals carrying mutations in multiple genes (Wang et al, 2013).
By revealing cellular pathways for scaffold-based and catalytic arrestin activation, the current papers provide fresh insights that might accelerate the discovery and validation of biased GPCR agonists as therapeutic agents.
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