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Deletions in this class appear not only to speed up senescence but also to accelerate the appearance of survivors.
Stresses on stem and progenitor cell pools, in the form of telomere shortening (Terc−/−) or other genome maintenance failures (ATRmKO, Ku86−/−, LIG4Y288C, XPDR722W/R722W, etc)., have been shown to degrade tissue renewal capacity and accelerate the appearance of age-related phenotypes.
This result suggests that the fixation of the guide cannula in the mouse brain did not accelerate the appearance of the clinical symptoms.
Exposing cells to high concentrations of, or prolonged incubation with, these factors might greatly accelerate the appearance of pathology in the cell culture environment.
Our results show that LPS can exacerbate neurodegeneration in the SN and aggravate and accelerate the appearance of behavioural symptoms in our Parkinson's disease model.
Deluca et al. reported that vitamin D was extremely effective in blocking the development of autoimmune disorder, and vitamin D deficiency could accelerate the appearance of symptoms and increased the severity of rheumatic disease.
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Increasing temperature or water-vapor concentration accelerated the appearance of breakaway oxidation.
The presence of oriented β-crystals accelerated the appearance of the yield point, and the yield point became the transition point from lamellar slip to fragmentation.
Nitrogen depletion accelerated the appearance of the fifth NMR signal component for Aviso leaves, whereas no differences were observed between the two N conditions in Express leaves (Fig. 7A, B).
Furthermore, co-delivery of rhesus GM-CSF as a genetic adjuvant with the HA DNA vaccine accelerated the appearance of, and significantly increased the magnitude of, neutralizing antibodies in the sera of immunized animals.
Loss of p53 activity inhibits apoptosis and accelerates the appearance of tumors in transgenic mice [ 27].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com