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However, they can react irreversibly with amino acid residues of peptides or proteins to form protein adducts or protein crosslinks., Alternatively, they can undergo further oxidation, dehydration, polymerization and oxidative breakdown reactions to give rise to numerous other AGEs., Oxygen, reactive oxygen species (ROS) and redox active transition metals accelerate AGE formation.
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There are, however, things that definitely accelerate aging: smoking, sun exposure, stress, overeating, a sedentary lifestyle, drug abuse, lousy DNA.
"Inflammation may accelerate aging in some people — but it is a manifestation of something that is occurring underneath".
The same p53 mechanism that protects us from cancer early in life may turn around later and accelerate aging.
Metabolic syndrome (MetS) and its components accelerate age-associated increases in arterial stiffness and thickness.
We used a mouse strain deleted for Sod2 in the RPE to accelerate age-related oxidative stress in the retina and to test the impact of 8-OH-DPAT on the photoreceptor and RPE degeneration developed in these mice.
Additionally, ROS may accelerate aging process and cause uneven pigmentation.
To simulate and accelerate ageing, biochars were oxidized in alkaline hydrogen peroxide for 4 months.
It can accelerate aging.
Alcoholism can cause or accelerate aging of the brain.
However, a role for oxidative stress, which is known to accelerate age-dependent liver peroxisomal damage [36] [38], might be hypothesized.
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