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Based on this mechanism of action, the rational design from the MO calculation of the conclusive activation energy to ii resulted in the four halogenated analogs with more potent activity than ACA (1).
In the course of search for the robust analogs of 1′-acetoxychavicol acetate (ACA, 1), the Rev-export inhibitor from the medicinal plant Alpinia galanga, we clarified formation of the quinone methide intermediate ii to be essential for exerting the inhibitory activity of 1.
The mitogenic and angiogenic effects of both CM were blocked by Aca 1, a peptide ObR antagonist, and by SU1498, which inhibits the VEGF receptor.
In the present work, we found that Aca 1 can abrogate leptin-induced tube formation and mitogenesis of HUVEC at 10 and 25 nM concentrations, respectively.
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Aligned Cluster Analysis (ACA) [29] and Hierarchical ACA (HACA) [30] apply temporal clustering of naturally occurring facial behaviour that solves for correspondences between dynamic events.
Preliminary results showed that annular dilatation caused a significant (p<0.05) decrease in anterior leaflet ACA (0.92±0.18 cm2), and combined annular dilatation and papillary muscle (PM) displacement resulted in a significant decrease in posterior leaflet ACA (0.87±0.15 cm2).
Thanks to the ACA, 20 million Americans have gained access to health care.
Under the ACA, 31 states and Washington, D.C. expanded Medicaid to cover 15 million of our fellow Americans.
TM-233 (Fig. 1a, lower panel) is a novel benzhydrol-type analog of ACA (1′-acetoxychavicol acetate) (Fig. 1a, upper panel), which we had previously developed 14 and which was dissolved in DMSO at a stock concentration of 10 mM.
Adenocarcinoma (ACA) was the most frequent histology among patients with EGFR mutations (ACA, 22/254 (8.7%) vs non-ACA, 5/298 (1.7%); p<0.001).
However, ACA 1.0 was ineffective in this respect.
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