Exact(1)
Indeed, reduced levels of these enzymes would still allow the formation of pathological species (albeit at a reduced rate) that could assemble into insoluble oligomers and fibrils, whereas clearance of oligomers (which is already inefficient when these enzymes are abundant) would be severely compromised.
Similar(58)
However, the relationship between essentiality and hubs could be artificial due to essential proteins generally being more abundant [ 44], and therefore methods biased toward abundant proteins would be artificially inflated with interactions involving essential proteins.
If the experimenter tends to select more abundant proteins for tagging, biases towards counting more interactions for abundant proteins would be amplified in a way that cannot be controlled for by transcript level.
Figure 5A F show that in the real GRNs of E. coli, S. cerevisiae and human, buffered motifs (blue) are much more abundant than would be expected by chance, while unbuffered (green and violet) motifs are much less abundant; and indeed, unbuffered motifs which are particularly susceptible to breaking BQS (violet) are rare.
Were the city located just a few kilometres further north, where cracks in the bedrock are abundant, it would be a different story: significant work might need to go into ground-floor ventilation.
"In areas where these guys are present and abundant, it would be a smart move, especially among ground-nesting birds, not to place eggs there," Laidre told the New Scientist.
Highly abundant transcripts would be more prone to reverse transcription and retroposition and this would explain the lower density of intronic sequences in highly transcribed regions [6].
Under this scenario, codons corresponding to abundant tRNA would be preferentially used [ 9- 12].
According to Wyllie and Leach, (1990), the most abundant peak would be the D and/or L isomer, whereas the other would be the meso isomer.
Genes with abundant RNA would be amplified without bias, but genes with low amounts of RNA might fail to be amplified accurately.
In this hypothesis, other lysosomal enzymes, and especially the abundant CPs, would be released into the cytoplasm and could participate in the degradation of cellular components.
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