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Since Pileou's Evenness Index and Simpson's Diversity Index are likely influenced by the very large number of unique clones in each specimen, we also compared the relative abundance of the ten most abundant T cell clones for each lesion between pairs.
In other words, there is a greater degree of clonal expansion of the ten most abundant T cell clones in brain metastases than primary lung cancers.
Analysis of the twenty most abundant T cell clones in tumor tissue shows that they account for about 60.0% of activated TILs (Fig. 5C).
Large positive spots judged to be S180 cells reflected that abundant T cells were presented on the surface of tumor cells.
Granulomatous tissue might be an ideal environment for HIV replication as abundant T cells, increased cell-cell interaction, and high TNF expression promote cell-cell transmission and virus replication [9], [40], [42].
At the peak of the immune response to LCMV, NP396-specific CD8 <img src="http://journals.plos.org/plosone/article/asset?id=info?doi/10.1371/journal.pone.0015959.e250.PNG" class= inline-graphic"/> T cells are the most abundant T cell population in the spleen, and yet this population constitutes only 6% of all splenocytes, which remains a fairly small fraction.
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Also, a set of 14 low abundant t-RNA synthetases were observed in the stroma with an average of −3.6, while soluble proteins involved in tetrapyrole biosynthesis have an average abundance of −3.3.
The SPIA™ system thus provides a reliable representation of the most abundant T-UCR transcripts.
Therefore, factors other than MSI may also be important for abundant T-cell responses in colorectal cancer.
γδTCR+ T cells are the most abundant T-cell class in the mammary epithelium but not in mammary carcinomas.
Only the less abundant T-UCRs have high intra-assay variability, consistently with the Poisson distribution statistics and stochastic effects on PCR repeatability.
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