Although only preliminary data is currently available to reach a significant conclusion, the vision of a stronger immunomodulatory effect of this upstream cell niche warrants further investigation as it, if found, may represent a possible readily-available and abundant stem cell progenitor alternative to bone marrow for cell-based tolerogenic regimens.
For example, the expression of a stemness gene or microRNA should be more abundant in stem cells and precursors than in fully differentiated and mature progenies.
Among genes enriched in yHCC, a subgroup of genes was also abundant in stem cells, especially in ESC.
In mammals, two proteins called Musashi1 and Musashi2 are abundant in stem cells and brain cancers, but are rarely found in specialized tissues and cells.
TRIM25 for example, a member of the TRIM protein superfamily that controls p53 activity (Zhang et al., accepted), is also more abundant in stem cells than in differentiated cells (Ping Zhang, unpublished results) and further proteins with such properties may exist.
In summary, our results indicate that the expression status of NS, abundant in stem cells, is a prognostic indicator in breast cancer patients, especially for those with luminal-type or HER2-type tumors, and that the coexpression of NS and p53 correlates with poorer prognostic outcomes.
Recent studies have identified an abundant source of stem cells termed adipose-derived adult stem (ADAS -cells in the subcutADAS -cellsose tinsue.
Recent research by neuroscientist Fred Gage and colleagues at the University of California (UC), San Diego, has shown that one of the most common types of jumping gene in people, called L1, is particularly abundant in human stem cells in the brain that ultimately differentiate into neurons and plays an important role in regulating neuronal development and proliferation.
ATM expression is abundant in neural stem cells (NSCs), but is gradually reduced as the cell differentiates [1], suggesting that ATM may play an essential role in NSC survival and function.
Bivalent genes, concurrently marked with both H3K4me3 and H3K27me3, were first identified as being abundant in embryonic stem cells (ES cells).
