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Abundant protein sequence databases and new powerful tools such as advanced computational structure modeling, multiple sequence analysis, and in vitro evolution have made it possible to understand the detailed reaction mechanisms of various ATs and to isolate and design novel enzymes for unnatural substrates.
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Amino acid repeats are abundant in protein sequences.
Amino acid repeats (AARs) are abundant in protein sequences.
Key Points Amino acid repeats are abundant in protein sequences.
e., atypical composition); translation was abundant in protein sequences with positive charge; and energy and translation functional classes showed residues with high molecular volume (Additional file 5).
Regions highly enriched in one or a few amino acids, known as low-complexity regions (LCRs), are strikingly abundant in protein sequences [ 1- 3].
Amino acid repeats (AARs) are abundant in protein sequences either as periodic elements in structural proteins such as collagens, keratins, silk and cell wall proteins, or as structural modules in functional proteins such as transcription factors, receptors, ion channels, histones, ubiquitins and calcium storage proteins.
Thus, we could discern 38 (RWS), 38 (xylose) and 11 (xylan) abundant protein clusters (more than 3 protein sequences per cluster in RWS and xylose; and more than 2 proteins per clusters in xylan) (Table 1; Additional files 2, 3).
The approach used both the labelled data instances collected from the available structures of protein-DNA complexes and the abundant unlabeled data found in protein sequence databases.
Sixteen families are made up of sequences contained within larger sequence blocks, either coding for abundant protein motifs or located within larger, ill-defined redundant intergenic sequences.
The most abundant protein (R20074237) was a novel protein with no sequence similarity to any sequences in SwissProt, GenBank, GenBank nr, or with any recognizable Pfam domains.
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