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An extreme case of competitive binding occurs when there is a large difference in affinity for or local abundance of the different competitors, as binding of the high-affinity or abundant partner will preclude the second partner from binding (3, 67, 68).
P-TEFb is a heterodimer consisting of cyclin-dependent kinase 9 (CDK9) and one of the C-type cyclins T1, T2a, or T2b of which cyclin T1 is the most abundant partner [ 10, 13].
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Finally, an interesting finding from our study was that H 2 ′ increased with the level of plant invasion, implying that species become more selective in their choice of mutualists by being compelled to interact with less abundant partners as invasion progresses.
The under-abundant population (red) grows faster than its neighboring over-abundant partner (green).
When the previously over-abundant partner becomes under-abundant (iii), piling-up in the opposite direction occurs (iv, green on red).
In conclusions, biochemical characterization of Rnd3 targets in mES cells by TAP tagging indicated Syx as a relatively abundant protein partner under our conditions.
The majority of the peptide reads were from the bait itself, but the most abundant interacting partner for the APA domains from mouse FCHo2 and SGIP1 was the AP2 complex (∼10% of peptides, Figure 7B and Figure 7 figure supplement 2).
In particular, microinjection of siRNA against the abundant pancRNA partner of interleukin 17d (Il17d) mRNA at the 1-cell stage caused embryonic lethality, which was rescued by supplying IL17D protein in vitro at the 4-cell stage.
Two of the nine storage proteins represented by antisense tags with cumulative abundances of 56 and 25 had low abundant sense partners with counts of 5 and 7 respectively, indicating the possibility that for these transcripts down-regulation is occurring via antisense transcription.
Analysis of the domain combinations in the trypsin-like proteins identified in the current study reveals the PDZ domains as the most abundant domain partners and their tethering to the C-terminal of the trypsin-like domain.
Abundant alternative mutualist partners with broad temporal distributions can make a mutualism more robust to climate change, while abundant alternative partners with narrow temporal distributions can make a mutualism less robust.
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