Lysine acetylation is abundant in large macromolecular complexes that function in chromatin remodeling, DNA damage, and cell-cycle control (Choudhary et al., 2009) and particularly in histones.
Acetylation is particularly abundant in large macromolecular complexes that are present in the cell nucleus, suggesting a key role of acetylation in the regulation of chromatin and transcriptional control.
Photoreactions in Biological Macromolecular Complexes (Introductory Remarks).
Grunwald, C. et al. From the Cover: In situ assembly of macromolecular complexes triggered by light.
Ray, P. S., Arif, A. & Fox, P. L. Macromolecular complexes as depots for releasable regulatory proteins.
Mutations in highly connected nodes alter protein protein interactions modulating macromolecular complexes enriched in disease risk candidates.
Chari, A. et al. ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space.
Macromolecular complexes embedded in the nuclear envelope physically couple the cytoskeleton to the nucleus.
Our scientists study macromolecular complexes and their specificity, protein design and evolution, and molecular networks.
A recurring challenge in cell biology is to define the molecular components of macromolecular complexes of interest.
