We conclude that a larger self-antigen load affects an increase in number of tissue resident antigen presenting cells (APCs) most likely due to compensatory antigen clearance mechanisms thereby enhancing the probability of productive T cell APC interactions in an antigen abundant environment and results in enhanced severity of autoimmune disease.
Therefore, there may be shared, but not identical, functionality between tapasin and TAPBPR regarding peptide selection onto HLA-A2, i.e. in a peptide abundant environment both chaperones could potentially load and edit peptides bound to HLA-A2.
The PFS assesses the psychological impact of living in food-abundant environments.
Although this increased efficiency is advantageous in energy-limited environments, in energy-abundant environments these individuals suffer from a higher incidence of diabetes, obesity and other metabolic disorders [11] [13].
Additionally, the presence of Fe3 + triggered resistance in otherwise non-permissive conditions, indicating that resistance induction is not limited to the macrophage phagosome, but may also occur in iron-abundant environments that may exist ex vivo (soil/water) or in vivo (stomach) after ingestion of iron-rich foods (Wösten et al., 2000).
This paper compares the fuelwood consumption strategies of households in a fuelwood-scarce environment against those in fuelwood-abundant environment in order to illustrate the inelastic nature of the demand for fuelwood in rural communities, even in the face of severely depleted wood stocks.
Dissolved and solid-phase HS can also serve as electron acceptors or donors for microorganisms [4, 16], resulting in reduced HS whose prevalence vary with the microbial community, but is expected to be abundant in environments such as reduced sediments and water logged soils.
Bacterial halophiles are abundant in environments such as salt lakes, saline soils.
IHAT analysis of the Global Ocean Sampling (GOS) dataset revealed that genes associated with polyphosphate metabolism are more abundant in environments where available phosphate is limited, suggesting an important role for polyphosphate metabolism in marine oligotrophs.
In fact, it is abundant in environments with moderate disturbance levels (Cohen and Ackerman 2009).
