Sentence examples for abundance variants from inspiring English sources

All NT and AA changes detected by Sanger sequencing were identified by pyrosequencing with the latter method showing a greater ability to detect low abundance variants.

There are also little data on the clinical significance of low abundance variants possessing TDRs in subjects who begin therapy with ritonavir-boosted protease inhibitor (PI -based theraPI -based

Item II(a) states that when the population size is large, since resources vary in abundance, variants with decreased entropy, and concomitantly decreased robustness, will now be more efficient in resource acquisition and utilization.

Despite the fact that this low abundance variant represents only 0.70%% of total peak area (see Fig.  3a), all diagnostic fragment ions as well as the intact mass of the protein were detected, albeit with higher mass errors for the low intensity fragments.

At least three categories of false positives were present: i) systematic positives in the PIK3CA locus that were present in both high and low quality FFPE samples; ii) low abundance variant calls that were below the threshold of the NGS-based confirmation assay (that is, <4%); and iii) positive calls that were within the range of analytical sensitivity of the confirmation assay (that is, ≥4%).

It has been previously shown that many of the low abundance resistant variants identified by UDS may not affect virologic outcomes if the resistant variants identified are only resistant to ARVs that are not part of the antiretroviral regimen being employed [14], [30].

In line with our discovery of a greater overall abundance of variants in the SSTI isolates we saw a significantly larger number of both synonymous and non-coding variants in the SSTI isolates when compared to the severe isolates.

Few studies have been able to control for the antiretroviral regimens used when investigating the impact of low abundance resistant variants on clinical outcomes.

Although low abundance resistant variants have been shown to be important in some HIV-infected populations, there are only limited data available on the rate of low abundance transmitted drug resistance (TDRs) mutations in diverse ARV-naïve populations infected with B and non-B HIV subtypes [17].

The overall TDR rate of 30.5% by UDS among ARV-naïve subjects in our study is similar to other investigations that reported rates between 28 to 33% depending on the populations studied and the sensitive genotyping methods used to identify low abundance resistant variants [14] [16], [24].

More investigation of transcript abundance and variants is needed to determine the biological significance of these gene pairs.